After a bike accident, the sweet-yet-nerdy 15-year-old Louise Miller knocks on the door of a strange-looking house, hoping to use the phone. Instead, she meets a strange but welcoming woman, the seer Madame Serena. Reading Louise's palm, Serena is stunned when she learns that Louise is a Reincarnation witch and an old friend from one of her previous lives. A week later, on Louise's 16th birthday, her magical powers return through a powerful amulet that was lost in a former life, an item that Madame Serena says searches for its owner.