Frank Murdoch (Joel Murray) is a middle-aged insurance salesman living in Syracuse, New York, who is sick with how the United States has fallen into a state of rudeness based on Popular culture, talk radio, television, and Internet influences. After a boring evening of watching television, Frank visualizes killing his loud and inconsiderate neighbors, whose baby's screams exacerbate his chronic migraine headaches and rob him of sleep. His ex-wife Alison (Melinda Page Hamilton) has custody of their daughter Ava (Mackenzie Brooke Smith), who has become a typical spoiled brat. Matters come to a head when he is fired after 11 years' service at the insurance company for obtaining a female co-worker's address without authority merely to send her roses to lift her spirits; then told by his profane and uninterested doctor that he has an inoperable, terminal brain tumor.