One night in the American South, a truck loaded with prisoners in the back swerves to miss another truck and crashes through a barrier. The rescuers clear up the debris and cover the men killed, however, two are missing: a black man shackled to a white man, because "the warden had a sense of humor." They are told not to look too hard as "they will probably kill each other in the first five miles." Nevertheless, a large posse and many bloodhounds are dispatched the next morning to find them. The two missing men are the black Noah Cullen and the white John "Joker" Jackson. Despite their mutual hatred, they are forced to cooperate, as they are chained together. At first their cooperation is motivated by self-preservation but gradually, they begin to respect and like each other.