''Toxic Crusaders'' cleaned up Toxie's act considerably. Toxie was still a grotesque mutant endowed with superhuman powers, but underneath it all, he was a good-hearted, law-abiding citizen of the fictional town of Troma Entertainment#Tromaville, New Jersey (the setting of most of Troma Entertainment's films). Another change from the films was that the toxic waste also mutated his mop into a sentient being that would sometimes battle enemies by itself or motion to Toxie ideas on how to solve problems. The villains were still polluters, albeit polluters from a different world. Hailing from the planet Smogula, Czar Zosta, Dr. Killemoff, and Psycho wreaked ecological havoc with the help of Tromaville's corrupt Mayor Grody. Bonehead, a street punk who bullied Melvin, joins them in the first episode.