Rahul (Tusshar Kapoor) is sincere and hardworking whilst Karan (Riteish Deshmukh) is just the opposite. Both are best friends and cool wannabes. When the city is rocked with a series of rape and killings, the police with psychiatrist/psychologist Dr. Screwvala (Anupam kher) are in search of this dreaded Serial Killer, and Rahul becomes the prime suspect, yet being innocent. Things take a funny turn when the job of nabbing Rahul is entrusted to a violent lady Inspector called Urmila Martodkar (Isha Koppikar). Urmila is taken to a salon and kept gagged with tape on her mouth while the doctor instructs how she has to be disguised, while she moans through the tape on her mouth. She enters Rahul's life on a pretext, and tries to seduce him into showing his true nature. Rahul falls in love with her and she loves him back, not remembering she is on a police force mission. By this time, Karan falls in love with D.K.(Rajendranath Zutshi) i.e. his boss's ex Kiran (Bobby Darling) who is actually the brother of Rekha (Neha Dhupia) a psychologist and Karan's ex college mate.